Disease severity and mortality caused by dengue in a dominican pediatric population. If early detection and management of dss is delayed, the morbidity and mortality from prolonged shock is high. In indonesia, dengue hemorrhagic fever dhf are caused by dengue virus infection which was. This was designed primarily as a clinical tool, but it also enables cases of sd to be differentiated into three specific subcategories severe vascular. Early resuscitation of dengue shock syndrome in children.
Sekitar 2,5 milyar 25 penduduk dunia mempunyai resiko untuk terkena infeksi virus dengue. Dengue syok syndrome dengue syok syndrome ialah dbd dengan gejala gelisah, nafas cepat, nadi teraba kecil, lembut atau tak teraba, tekanan nadi menyempit misalnya sistolik 90 dan diastolik 80 mmhg, jadi tekanan nadi 20mmhg, bibir biru, tangan kaki dingin, dan tidak ada produksi urin. Dengue haemorrhagic fever, dengue shock syndrome, risk factors, predictor, haematocrit introduction dengue fever is an endemic infective disease in malaysia. Banyak juga pasien yang datang ke rumah sakit sudah dalam keadaan berat, bahkan dalam keadaan syok dengue shock syndrome dss, suatu keadaan yang paling berat dari demam berdarah. Dengue shock syndrome is the most severe from of dengue haemorrhagic fever, one of the leading causes of death in children. Dengue fever also known as breakbone fever, is a mosquitoborne topical disease caused by the dengue virus dengue fever, a benign syndrome caused by several arthropodborne viruses dengue fever 3. Case presentation on dengue fever, dengue shock syndrome 2. Guidelines for clinical management of dengue fever, dengue hemoragic fever, dengue shock syndrome. Demam dengue merupakan demam bifase akut yang ditandai dengan sakit kepala, mialgia, artralgia, ruam kulit dan leukopenia. Dengue is caused by one of four viral serotypes closely related viruses, designated den1, den2, den3, and den4.
Dengue shock syndrome causes high morbidity and mortality among children worldwide. Corticosteroids in the treatment of dengue shock syndrome. Pdf background dengue hemorrhagic fever dhf can lead to highmorbidity and mortality. Corticosteroids for treating dengue shock syndrome request pdf.
Characteristics of dengue shock syndrome match who markers. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. This has incorporated several atypical findings of dengue. Based on a clinical diagnosis of dengue shock syndrome dss plus myocarditis, dobutamine and noradrenaline infusions were started. Namun sampai saat ini mekanisme respons imun pada infeksi oleh virus dengue masih belum jelas, banyak faktor yang mempengaruhi kejadian penyakit demam berdarah dengue, antara lain faktor host, lingkugan environment dan faktor virusnya sendiri. Pasien dapat mengalami syok hipovolemik penurunan cairan akibat kebocoran plasma. Dengue shock syndrome is severe, and can lead to excessive bleeding and even death. Penatalaksanaan dengue shock syndrome dss penatalaksanaan medis, penatalaksanaan medik, penanganan medis, protap,prosedur tetap,gawat darurat, emergency. Warning signs include sustained abdominal pain, vomiting, irritability or somnolence, a fall in body temperature and decrease in platelet count 10.
Berikan 20 mlkg larutan kristaloid seperti ringer laktatasetat secepatnya. Jan 22, 2016 dalam artikel kali ini saya hanya akan menuliskan kriteria diagnosis demam dengue dan dbd. Clinical findings include nausea, vomiting, rash, aches and pains, a positive tourniquet test, leukopenia, and the following. In a small proportion of cases, the disease develops into severe dengue, also known as dengue. It is transmitted by mosquitoes of the genus aedes, which are widely distributed in subtropical and tropical areas of the world see the image below. This is the part of the blood that is first to come out of the blood vessels. Dengue viral infections are one of the most important mosquito borne diseases in the world. Derajat diagnosis juga harus ditentukan, terutama pada keadaan dengue shock syndrome dss yang merupakan bagian demam dengue yang paling membutuhkan diagnosis akurat karena bersifat fatal dan dapat mengancam nyawa.
The autoimmune mechanism in dengue hemorrhagic fever. Salah satu kasus infeksi virus dengue dengan angka kematian paling tinggi adalah dengue shock syndrome dss, kirakira 7%. Corticosteroids for treating dengue shock syndrome. Dengue shock syndrome dss is associated with almost 50% mortality. Ninety percent of dhf subjects are children less than 15 years of age. Abstract shock is life threatening feature of dhf it must be manage properly through close clinical and laboratory observations. Risk factors associated with development of dengue. Apabila terjadi perburukan klinis berikan tatalaksana sesuai dengan tata laksana syok terkompensasi compensated shock. Repeat platelet count was 22,000mm 3 and the hematocrit 48%. Itu adalah gambaran kalau pasien diterapi secara adekuat. Other articles where dengue shock syndrome is discussed. These serotypes are members of the flavivirus genus, which also contains the viruses that cause yellow fever, and can occur in any country where. Dengue hemmorhagic fever dhf adalah penyakit infeksi yang disebabkan oleh virus dengue dengan tanda dan gejala demam, nyeri otot, nyeri sendi disertai lekopenia, ruam, limfadenopati, trombositopenia rohim, 2004.
Dengue chapter 4 2020 yellow book travelers health. Penatalaksanaan dengue shock syndrome dss penatalaksanaan. Worldwide, children younger than 15 years make up 90% of dhf cases. Kegawatan demam berdarah dengue pada anak sari pediatri. The immune response of dengue feverdengue hemorrhagic fever is a series of immunopathogenesis. Dengue shock syndrome symptoms, causes, diagnosis, and treatment information for dengue shock syndrome dengue fever with alternative diagnoses, fulltext book chapters, misdiagnosis, research treatments, prevention, and prognosis. Dalam artikel kali ini saya hanya akan menuliskan kriteria diagnosis demam dengue dan dbd. In a press conference at the parang elementary school in marikina city, the school where the ceremonial dengue vaccination was held in april 2016, duque said the clinical charts and records of the 14 child vaccinees clearly showed that most of them succumbed to dengue shock syndrome. This study aimed to analyze ferritin serum as a predictor of shock in children with dengue infection, and to determine the cut off point that can be. Dec 11, 2014 dengue fever df is the most prevalent arthropodborne viral disease affecting humans. May 03, 2019 in 2030% of dhf cases, the patient develops shock, known as the dengue shock syndrome dss. Dengue, caused by ss rna virus flavivirus, is most rapidly spreading mosquito borne viral disease in the world. Nov 06, 2017 dengue complications the symptoms of dengue hemorrhagic fever can trigger dengue shock syndrome.
Annually, 100 million cases of dengue fever and half a million cases of dhf occur worldwide. The first major outbreak of dengue haemorrhagic fever dhf. The who estimates that 50100 million cases of dengue infection occur annually, with approximately 500,000 of those cases resulting in dengue hemorrhagic fever dhf, with an estimated 22,000 deaths per year, mostly in children. The world health organization who proposed a revised classification in 2009 to enable the more effective identification of cases of severe dengue sd. Pdf clinical features of dengue hemorrhagic fever and risk factors. Clinical and laboratory characteristics of dengue shock syndrome in children complied with current who guidelines as markers of severe disease and presented variables to. Dengue is the most important mosquitotransmitted viral disease in terms of morbidity and mortality dengue is a homonym for the african ki denga pepo. This was a preeliminary study to evaluate hematocrit hct increased where shock occurs on dengue hemorrhagic fever dhf or dengue shock syndrome dss. Malaysia reported its first case of df in 1902 and dhf in 1962. Tata laksana kegawatan dbd berorientasi pada pendekatan patofisiologik multi system terpadu.
Banyak juga pasien yang datang ke rumah sakit sudah dalam keadaan berat, bahkan dalam keadaan syok dengue shock syndromedss, suatu keadaan yang paling berat dari demam berdarah. Corticosteroids in the treatment of dengue shock syndrome senaka rajapakse,1 chaturaka rodrigo,1 sachith maduranga,1 anoja chamarie rajapakse21department of clinical medicine, faculty of medicine, university of colombo, colombo, sri lanka. Dengue shock syndrome is a leading cause of mortality among indian children. Several laboratory monitoring can be used to evaluate the progressivity of dengue virus infection. Expanded dengue syndrome manifestation yang tidak lazim, dengue dengan komplikasi, keterlibatan organ lain enam rumah sakit di jakarta, klb tahun 2004 expanded dengue syndrome 205 46. Secondary infection by a different dengue virus serotype has been confirmed as an important risk factor for the development of dhf. Study patients included 103 with dengue fever df, dengue hemorrhagic fever dhf, and dengue shock syndrome dss, as diagnosed by the world health organization criteria. Buku ajar gastroenterologi hepatologi, ed 1, badan penerbitan idai. Serum ferritin as a predictor of shock in children with. Although the mortality rate from all forms of treated dhf ranges from 1% to 26%, the mortality rate of severe dss may approach 47%, with one study reporting survival of only one of three children with dss and acute respiratory. Demam berdarah dengue ditandai dengan manifestasi klinis utama yaitu demam tinggi, fenomena hemoragik, sering dengan hepatomegali dan pada kasus berat ada tandatanda kegagalan sirkulasi. In november 2009, the world health organization who issued a new guideline that classifies symptomatic cases as dengue or severe dengue.
Aggressive management of dengue shock syndrome may decrease. Demam dengue juga disebut sebagai breakbone fever atau bonebreak fever demam sendi widyastuti,palupi. Keadaan seperti ini tentu saja harus diatasi dengan meningkatkan kewaspadaan kita semua, masyarakat dan pemerintah, khususnya dalam hal mencegah penularan dan. Penatalaksanaan demam dengue dengue feverdf karena bersifat. Berdarah dengue yang berat atau dengue shock syndrome dss. Berdasar petunjuk klinis tersebut dibuat kriteria diagnosis klinis, yang terdiri atas kriteria diagnosis klinis demam dengue dd, demam berdarah dengue dbd, demam berdarah dengue dengan syok sindrom syok denguessd, dan expanded dengue syndrome unusual manifestation.
Dengue is the most common and important arthropodborne viral arboviral illness in humans. Setelah diperiksa pada tn a ditemukan keadaan umum. Background dengue fever df and dengue hemorrhagic fever dhfdengue shock syndrome dss continue to be significant causes of morbidity and mortality in the philippines. Dhf may progress to hypovolemic shock known as dss.
Mar 24, 2017 salah satu kasus infeksi virus dengue dengan angka kematian paling tinggi adalah dengue shock syndrome dss, kirakira 7%. Dengue in the context of the imci i dengue, dengue haemorrhagic fever and dengue shock syndrome in the context of the integrated management of childhood illness department of child and adolescent health and development discussion papers on child health dengue in the context of the imci cah whofchcah05. Severity of this disease ranges from undifferentiated acute febrile illness to df or dengue hemorrhagic fever dhf dengue shock syndrome dss, which are associated with variable plasma leak. Directorate of national vector borne isease control programme. Derajat diagnosis juga harus ditentukan, terutama pada keadaan dengue shock syndrome dss yang merupakan bagian demam dengue yang paling membutuhkan diagnosis akurat karena bersifat fatal dan dapat mengancam nyawa anamnesis. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever dhf, and eventually dengue shock syndrome dss. Dengue fever,dengue shock syndrome linkedin slideshare. Observational studies have suggested corticosteroids may benefit people. As both cell tropism and tissue tropism of denv are considered major determinants in the pathogenesis of dengue, there is a critical need for adequate tropism assays, animal models, and human autopsy data. Dengue viral infections postgraduate medical journal.
Our objective was to compare the effectiveness of the recommended volume of rl versus a smaller volume of a hypertonic sodium lactate solution hsl in children with dss. Aggressive management of dengue shock syndrome may. As the disease spreads to new geographical areas, the frequency of the outbreaks is increasing along with a changing disease epidemiology. Pedoman diagnosis dan tatalaksana infeksi virus dengue. Clinical characteristics and risk factors of dengue shock. Dengue shock syndrome caused most of 14 deaths manila. Risk factors of dengue shock syndrome in children journal. Jul 15, 2009 based on a clinical diagnosis of dengue shock syndrome dss plus myocarditis, dobutamine and noradrenaline infusions were started. Sekitar 2,5 milyar 25 penduduk dunia mempunyai resiko untuk. Dengue fever is a mosquitoborne tropical disease caused by the dengue virus. Dengue fever also known as breakbone fever, is a mosquitoborne topical disease caused by the dengue virus dengue fever, a benign syndrome. Dengue complications the symptoms of dengue hemorrhagic fever can trigger dengue shock syndrome. Delhi recorded huge outbreaks of dengue fever df during the years 1967, 1970, 1982, 1988, 1991, 1992, 1996, 20012003, 2006, 2008 and 2009 and still maintains high vulnerability. Duque explained that the dengue shock syndrome is a grade four classification, according to the world health organization.
It is a major cause of morbidity and mortality in southeast asia, including india. Namun sampai saat ini mekanisme respons imun pada infeksi oleh virus dengue masih belum jelas, banyak faktor yang mempengaruhi kejadian penyakit demam berdarah dengue, antara lain faktor host, lingkugan environment dan. Sep 25, 2016 demam dengue merupakan demam bifase akut yang ditandai dengan sakit kepala, mialgia, artralgia, ruam kulit dan leukopenia. Effectiveness of vitamin d in prevention of dengue. May 03, 2019 the first dengue hemorrhagic fever epidemic in the americas occurred in cuba in 1981 and involved serotype 2 dengue denv2, with hundreds of thousands of cases of dengue in both children and adults, 24,000 cases of dengue hemorrhagic fever, 10,000 cases of dengue shock syndrome, and 158 reported deaths. Current and historical conditions indexed list of current and historical nationally notifiable conditions. Ninety percent of dhf subjects are children less than 15. Dengue hemorrhagic fever dhf and dengue shock syndrome dss occur as seasonal epidemics in the tropics and are important causes of death in asian children. Syok berat profound shock, nadi tidak dapat diraba dan tekanan darah tidak terukur. Dengue shock syndrome dss fluid resuscitation by following the world health organization who guideline usually required large volumes of ringer lactate rl that might induce secondary fluid overload. Dengue shock syndrome it can be life threatening youtube. Pedoman diagnosis dan tatalaksana infeksi virus dengue pasien.
The incidence of dengue has increased dramatically in recent decades, with estimates of 40%50% of the worlds population at risk for the. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever dhf, or dengue shock syndrome. The objective of this study was to compare outcomes duration of ventilation, pediatric intensive care unit stay, incidence of acute respiratory distress syndrome, and intensive care unit and hospital. Pitfalls pada diagnosis dan tata laksana infeksi dengue 27. Jadi kalau kamu dapat 15 pasien dss dalam sebulan, kemungkinan yang meninggal adalah 1 orang. Disease burden of dengue fever and dengue haemorrhagic fever. This study aimed to analyze ferritin serum as a predictor of shock in children with dengue infection, and to determine the cut off point that can be used to diagnose dengue shock. Fluids were given with caution, and fresh frozen plasma ffp and platelet transfusion was commenced. Dengue shock syndrome dan expanded dengue syndrome akan dibahas pada artikel yang lain, atau dapat juga dibaca di buku pedoman diagnosis dan tata laksana infeksi virus dengue pada anak dari idai terbaru. Symptoms typically begin three to fourteen days after infection.
Buku ajar gastroenterologi hepatologi, ed 1, badan penerbitan idai, jakarta,2010, hal 3240. Diagnosis demam dengue dengue fever df ditegakkan dari anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Dengue guidelines for diagnosis, treatment, prevention and control dengue guidelines for diagnosis, treatment, prevention and control new edition neglected tropical diseases ntd tdr world health organization hivaids, tuberculosis and malaria htm 20, avenue appia world health organization 1211 geneva 27. Dengue fever df is the most prevalent arthropodborne viral disease affecting humans.
Dengue virus has not been enlisted as a common etiological agent in several conditions like encephalitis, guillain barre syndrome. It is an arboviral infection caused by the family flaviviridae. In january 2000, we instituted a protocol for aggressive management of children with dengue shock syndrome. Preventive transfusion in dengue shock syndrome is it necessary.
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